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Aimé Cotton Laboratory

Optimized versatile surface engineering of lanthanide cation-doped γ-maghemite nanoparticles

Jean-Paul LELLOUCHE, Department of Chemistry, Institute of Nanotechnology & Advanced Materials (BINA), Bar-Ilan University, Israel, will give a lecture about "Optimized versatile surface engineering of lanthanide cation-doped γ-maghemite nanoparticles: siRNA-mediated gene silencing in the case of ovarian cancer".
Le 19/07/2018 : 11:00 à 12:30
Ajouter à mon agenda 2024-03-28 08:42:43 2024-03-28 08:42:43 Optimized versatile surface engineering of lanthanide cation-doped γ-maghemite nanoparticles Jean-Paul LELLOUCHE, Department of Chemistry, Institute of Nanotechnology & Advanced Materials (BINA), Bar-Ilan University, Israel, will give a lecture about "Optimized versatile surface engineering of lanthanide cation-doped γ-maghemite nanoparticles: siRNA-mediated gene silencing in the case of ovarian cancer". Aimé Cotton Laboratory, Balmer room ENS-PARIS-SACLAY webmaster@ens-paris-saclay.fr Europe/Paris public

Iron oxide (FexOy) nanoparticles (NPs) are currently widely used in numerous biotechnology applications. But serious drawbacks like challenging detrimental NPs aggregation and controlled NPs surface functionalization versatility request quite innovative solutions.

Our recent R&D work in this field [1] led to the discovery of a novel method/concept for promoting (i) the effective anti-aggregation control of 5.0-6.5 nm-sized hydrophilic super-paramagnetic maghemite (γ-Fe2O3) NPs, and (ii) its successful use for NPs functionalization/versatile NPs surface engineering toward siRNA-mediated gene delivery/silencing cancer therapy-relevant applications.

Such an innovative multi-parameters NPs surface engineering methodology also exploited an effective controlled Design of Experiment (DoE) globally optimized
high-power ultrasound (US)-assisted lanthanide metal Ce(III/IV) cation/complex doping of the NPs surface towards 45/50 nm-sized (DLS) maghemite NPs. This US-nanofabrication led to highly positive hydrophilic NPs.

Such a powerful Ce3/4+ cation/complex-doping process enabled (i) an effective charge control of potential NPs aggregation, (ii) a full NPs water compatibility for biological applications, and finally (iii) a successful development of quite versatile surface engineering chemistries using its Ce3/4+ cation/complex-based coordination chemistry involving any Lewis basis biomolecule/organic species (e.g. hyaluronic/alginic acids, 25 kDa polyethyleneimine…) covalent binding, which enables 2nd step chemical modifications.

We will show that such a versatile NPs surface engineering enabled the discovery of specifically chemically modified γ-Fe2O3 NPs that disclosed powerful anti-ovarian cancer cell activity (tumor progression stopping) via specific effective PLK-1 siRNA delivery.

[1] J.-P. Lellouche et al., Magnetic Inorganic Iron-Based Nanoparticles - Generalities and Use in Drug Delivery,
Patent Application, 2014, PCT/IL2014/050064.

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